Just published our latest paper on high insulin

diabesity paper.jpg

We’re really proud of this piece of work by Catherine Crofts under the guidance of myself and Dr Caryn Zinn. A great review paper on how high insulin underpins all of chronic disease. Just out in the journal Diabesity

Full text here. Abstract below


Diabesity 2015; 1 (4): 34-43 doi: 10.15562/diabesity.2015.19 http://www.diabesity.ejournals.ca


Hyperinsulinemia: A unifying theory of chronic disease?

Catherine A.P Crofts*1, Caryn Zinn1, Mark C Wheldon2, Grant M Schofield1



Globally, there is an increasing prevalence of non-communicable diseases. The morbidity and mortality from these conditions confer a greater economic societal burden. Epidemiological research associates insulin resistance in the etiology of these diseases, but there is limited evidence for the mechanism of damage. Emerging research suggests that hyperinsulinemia, a symptom of insulin resistance, may cause these pathological changes, and therefore be an independent contributor to these diseases. This review shows that hyperinsulinemia, or excessive insulin secretion, should be considered independently to insulin resistance, defined as glucose uptake rate, even though the two conditions are intertwined and will co-exist under normal conditions. Hyperinsulinemia directly and indirectly contributes to a vast array of metabolic diseases including all inflammatory conditions, all vascular diseases, gestational and type 2 diabetes, non-alcoholic fatty liver disease, obesity and certain cancers and dementias. The mechanisms include increased production of: insulin growth factor-1; reactive oxidative species and advanced glycation end-products; and triglyceride and fatty acids. Hyperinsulinemia also directly and indirectly affects many other hormones and cytokine mechanisms including leptin, adiponectin and estrogen. There is limited research standardizing the hyperinsulinemia diagnostic process. Methodological concerns and lack of standardized reference ranges preclude the use of fasting insulin. Most research has also focused on insulin resistance and it is unknown whether these methods translate to hyperinsulinemia.

Keywords: Hyperinsulinemia, hyperglycemia, type 2 diabetes, insulin resistance, secretagogue, syndrome x’


10 Comments on “Just published our latest paper on high insulin

  1. You’re like ahead of your time..that is if your time was 40 years ago and then you’d be 20 years ahead.
    Google Dr. Rosedale’s talk on insulin /diabetes

    • Zag about your comment: one day you WILL have something go wrong with your body. Let’s hope that doctors can fix it, but if they cannot (as in the case of my wife’s illnesses), you will realise that the current wisdom that doctors spout as gospel, has little relevance to disease. Then you will remember the wisdom and truth Prof Grant is talking about. It is easy to criticise when healthy. Live long and prosper.

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  3. I’m sure you’ve heard heaps of similar stories… A GP was commenting that one her insulin dependent diabetic patients (of 25 years) had completely stopped taking insulin, had never felt better, lost weight and she was satisfied all indicators were stable after going LCHF.

  4. pretty good article, but really doesnt explain why the body produces more insulin thennecessary unless the cells are resistant or there is a genetic compoent or the brain is not getting the insulin message or what not. for me metabolic syndrome has been a bear to deal with the only thing that seemed to turn the tide in dealing with symptoms like sleeplessness and hypoglycemic symptoms for example was vitad3 supplementation to top up the fat cells (like 100,000 iu per day for a month htendown to 10,000 for a few months) stop for a while then redosing for a couple of years until I jsut stopped. sleep better now and feel better but improvement can still be had,like weight loss, some fatigue, (not as bad) myheavy periods were something else but menopause took care of that, I am still a mess but a more managable one.

    • I suspect the excessive insulin is produced in response to excessive carb consumption of the high carb diet. A diet our bodies are not designed to consume. I also suspect that those who are more susceptable have likely been exposed to epigenetic changes in utero or during early life aka fetal origins of health and disease (FOHaD) and that the gut microbiome also plays a crucial role.

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